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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
ILEU_HUMAN
USC-OGP 2-DE database
:
ILEU_HUMAN
ILEU_HUMAN
General information about the entry
View entry in simple text format
Entry name
ILEU_HUMAN
Primary accession number
P30740
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Leukocyte elastase inhibitor; Short=LEI; AltName: Full=Monocyte/neutrophil elastase inhibitor; Short=EI; Short=M/NEI; AltName: Full=Peptidase inhibitor 2; Short=PI-2; AltName: Full=Serpin B1;.
Gene name
Name=SERPINB1
Synonyms=ELANH2, MNEI, PI2
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-7
{PLATELET 4-7}
Homo sapiens (Human)
map experimental info
PLATELET_4-7
MAP LOCATIONS:
SPOT OGP-0406
:
pI=5.66; Mw=43166
SPOT OGP-0409
:
pI=5.72; Mw=42642
SPOT OGP-0411
:
pI=5.82; Mw=42538
PLATELET_5-6
{PLATELET 5-6}
Homo sapiens (Human)
map experimental info
PLATELET_5-6
MAP LOCATIONS:
SPOT OGP-0702
:
pI=5.83; Mw=44200
SPOT OGP-0706
:
pI=5.68; Mw=43115
SPOT OGP-0710
:
pI=5.79; Mw=42372
PLATELET_6-11
{PLATELET 6-11}
Homo sapiens (Human)
map experimental info
PLATELET_6-11
MAP LOCATIONS:
SPOT OGP-0944
:
pI=5.65; Mw=42003
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1185
:
pI=6.07; Mw=43048
Cross-references
UniProtKB/Swiss-Prot
P30740; ILEU_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
ILEU_HUMAN
Primary accession number
P30740
Secondary accession number(s)
A8K5L2 B4DNT0 Q53FB9 Q5W0E1 Q9UDF8
Sequence was last modified on
April 1, 1993 (version 1)
Annotations were last modified on
March 15, 2017 (version 166)
Name and origin of the protein
Description
RecName: Full=Leukocyte elastase inhibitor; Short=LEI; AltName: Full=Monocyte/neutrophil elastase inhibitor; Short=EI; Short=M/NEI; AltName: Full=Peptidase inhibitor 2; Short=PI-2; AltName: Full=Serpin B1;
Gene name
Name=SERPINB1
Synonyms=ELANH2, MNEI, PI2
Encoded on
Name=SERPINB1; Synonyms=ELANH2, MNEI, PI2
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Phosphoprotein
;
Polymorphism
;
Protease inhibitor
;
Reference proteome
;
Serine protease inhibitor
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M93056; -
; NOT_ANNOTATED_CDS; mRNA
EMBL
AF053630; AAC31394.1
; -; Genomic_DNA
EMBL
AK291327; BAF84016.1
; -; mRNA
EMBL
AK298044; BAG60342.1
; -; mRNA
EMBL
BT006928; AAP35574.1
; -; mRNA
EMBL
AK223370; BAD97090.1
; ALT_INIT; mRNA
EMBL
AL139092; CAH73667.1
; -; Genomic_DNA
EMBL
BC009015; AAH09015.1
; -; mRNA
CCDS
CCDS4477.1; -. [P30740-1]
; .
PIR
S27383; S27383
; .
RefSeq
NP_109591.1; NM_030666.3. [P30740-1]
; .
RefSeq
XP_011512635.1; XM_011514333.1. [P30740-1]
; .
RefSeq
XP_011512636.1; XM_011514334.2. [P30740-1]
; .
UniGene
Hs.381167; -
; .
PDB
4GA7; X-ray
; 2.90 A; A/B=1-379
PDBsum
4GA7; -
; .
ProteinModelPortal
P30740; -
; .
SMR
P30740; -
; .
BioGrid
108307; 20
; .
IntAct
P30740; 2
; .
MINT
MINT-4999893; -
; .
STRING
9606.ENSP00000370115; -
; .
MEROPS
I04.006; -
; .
iPTMnet
P30740; -
; .
PhosphoSitePlus
P30740; -
; .
DMDM
266344; -
; .
OGP
P30740; -
; .
REPRODUCTION-2DPAGE
IPI00027444; -
; .
EPD
P30740; -
; .
PaxDb
P30740; -
; .
PeptideAtlas
P30740; -
; .
PRIDE
P30740; -
; .
DNASU
1992; -
; .
Ensembl
ENST00000380739; ENSP00000370115
; ENSG00000021355. [P30740-1]; .
GeneID
1992; -
; .
KEGG
hsa:1992; -
; .
CTD
1992; -
; .
DisGeNET
1992; -
; .
GeneCards
SERPINB1; -
; .
HGNC
HGNC:3311; SERPINB1
; .
HPA
HPA018871; -
; .
HPA
HPA052642; -
; .
MIM
130135; gene
; .
neXtProt
NX_P30740; -
; .
OpenTargets
ENSG00000021355; -
; .
PharmGKB
PA35046; -
; .
eggNOG
KOG2392; Eukaryota
; .
eggNOG
COG4826; LUCA
; .
GeneTree
ENSGT00760000118789; -
; .
HOGENOM
HOG000238519; -
; .
HOVERGEN
HBG005957; -
; .
InParanoid
P30740; -
; .
KO
K13963; -
; .
OMA
DRKTVKM; -
; .
OrthoDB
EOG091G0ION; -
; .
PhylomeDB
P30740; -
; .
TreeFam
TF352619; -
; .
Reactome
R-HSA-6798695; Neutrophil degranulation
; .
ChiTaRS
SERPINB1; human
; .
GeneWiki
SERPINB1; -
; .
GenomeRNAi
1992; -
; .
PMAP-CutDB
P30740; -
; .
PRO
PR:P30740; -
; .
Proteomes
UP000005640; Chromosome 6
; .
Bgee
ENSG00000021355; -
; .
CleanEx
HS_SERPINB1; -
; .
ExpressionAtlas
P30740; baseline and differential
; .
Genevisible
P30740; HS
; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005576; C:extracellular region
; TAS:Reactome; .
GO
GO:0005615; C:extracellular space
; IDA:UniProtKB; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0034774; C:secretory granule lumen
; TAS:Reactome; .
GO
GO:0004867; F:serine-type endopeptidase inhibitor activity
; NAS:UniProtKB; .
GO
GO:0043312; P:neutrophil degranulation
; TAS:Reactome; .
InterPro
IPR015557; Serpin_B1
; .
InterPro
IPR023795; Serpin_CS
; .
InterPro
IPR023796; Serpin_dom
; .
InterPro
IPR000215; Serpin_fam
; .
PANTHER
PTHR11461; PTHR11461
; 1; .
PANTHER
PTHR11461:SF263; PTHR11461:SF263
; 1; .
Pfam
PF00079; Serpin
; 1; .
SMART
SM00093; SERPIN
; 1; .
SUPFAM
SSF56574; SSF56574
; 1; .
PROSITE
PS00284; SERPIN
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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